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1. (WO2014197535) RECOMBINANT CANCER THERAPEUTIC CYTOKINE

Pub. No.:    WO/2014/197535    International Application No.:    PCT/US2014/040793
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Thu Jun 05 01:59:59 CEST 2014
IPC: C07K 14/52
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY
Inventors: FISHER, Paul, B.
BHOOPATHI, Praveen
DAS, Swadesh, K.
EMDAD, Luni
SARKAR, Devanand
SOKHI, Upneet
Title: RECOMBINANT CANCER THERAPEUTIC CYTOKINE
Abstract:
Recombinant therapeutic cytokines ("therakines") for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 ("M4") not normally found in nature that has anli-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.