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Pub. No.:    WO/2014/197535    International Application No.:    PCT/US2014/040793
Publication Date: 11.12.2014 International Filing Date: 04.06.2014
C07K 14/52 (2006.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 800 East Leigh Street Richmond, VA 23219 (US)
Inventors: FISHER, Paul, B.; (US).
BHOOPATHI, Praveen; (US).
DAS, Swadesh, K.; (US).
EMDAD, Luni; (US).
SARKAR, Devanand; (US).
SOKHI, Upneet; (US)
Agent: VAVRA, Stephanie H.; (US)
Priority Data:
61/830,814 04.06.2013 US
Abstract: front page image
(EN)Recombinant therapeutic cytokines ("therakines") for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 ("M4") not normally found in nature that has anli-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.
(FR)La présente invention concerne des cytokines thérapeutiques recombinantes ("thérakines") pour le traitement du cancer. Lesdites thérakines recombinantes comprennent une région tronquée de MDA-7/TL-24 ("M4"), qui ne se trouve pas normalement à l'état naturel et possède une activité anticancéreuse, et un signal de sécrétion. Ledit signal entraîne la sécrétion de la thérakine à partir de cellules cancéreuses et normales transduites avec un plasmide/virus, et l'interaction de la thérakine dans des récepteurs MDA-7/IL-24 sur les cellules cancéreuses adjacentes, voisines et distantes. L'interaction de la thérakine entraîne la mort de voisinage de la cellules cancéreuse cible ainsi que des cellules cancéreuses adjacentes, voisines et distantes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)