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1. (WO2014197471) HISTONE DEACETYLASE ( HDAC) BIOMARKERS IN MULTIPLE MYELOMA

Pub. No.:    WO/2014/197471    International Application No.:    PCT/US2014/040696
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Wed Jun 04 01:59:59 CEST 2014
IPC: C07K 7/08
G01N 33/53
G01N 33/574
Applicants: ACETYLON PHARMACEUTICALS, INC.
Inventors: YANG, Min
JONES, Simon, S.
Title: HISTONE DEACETYLASE ( HDAC) BIOMARKERS IN MULTIPLE MYELOMA
Abstract:
The invention relates to histone deacetylase (HDAC) biomarkers in multiple myeloma. Specifically, the biomarkers are drug specific, histone deacetylase (HDAC) or HDAC6 biomarker peptides, which are acetylated, for multiple myeloma. Alternatively, the biomarkers are drug specific, HDAC6 biomarker peptides, which are acetylated or unacetylated, for multiple myeloma. The invention also relates to a kit comprising a detection agent and instructions for identifying a biomarker peptide of the invention. The invention further relates to a method for monitoring treatment efficiency of an HDAC inhibitor in a subject.