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1. (WO2014197423) FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) METHODOLOGY USING TRANSVERSE RELAXATION PREPARATION AND NON-ECHO-PLANAR IMAGING (EPI) PULSE SEQUENCES

Pub. No.:    WO/2014/197423    International Application No.:    PCT/US2014/040603
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Wed Jun 04 01:59:59 CEST 2014
IPC: A61B 5/055
Applicants: THE JOHNS HOPKINS UNIVERSITY
KENNEDY KRIEGER INSTITUTE, INC.
Inventors: HUA, Jun
JONES, Craig Kenneth
QIN, Qin
VAN ZIJL, Peter
Title: FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) METHODOLOGY USING TRANSVERSE RELAXATION PREPARATION AND NON-ECHO-PLANAR IMAGING (EPI) PULSE SEQUENCES
Abstract:
An embodiment in accordance with the present invention provides a new acquisition scheme for T2-weighted BOLD fMRI. It employs a T2 preparation module to induce the BOLD contrast, followed by a single-shot 3D fast gradient echo (GRE) readout with short echo time (TE<2ms). The separation of BOLD contrast generation from the readout substantially reduces the "dead time" due to long TE required in spin echo (SE) BOLD sequences. This approach termed "3D T2prep-GRE," can be implemented with any magnetic resonance imaging machine, known to or conceivable by one of skill in the art. This approach is expected to be useful for ultra-high field fMRI studies that require whole brain coverage, or focus on regions near air cavities. The concept of using T2 preparation to generate BOLD contrast can be combined with many other fast imaging sequences at any field strength.