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1. (WO2014197369) COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT PREVENTION, AND TREATMENT OF CANCER USING PD-L1 ISOFORMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/197369    International Application No.:    PCT/US2014/040504
Publication Date: 11.12.2014 International Filing Date: 02.06.2014
IPC:
G01N 33/50 (2006.01)
Applicants: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Boston, MA 02215-5450 (US)
Inventors: HAMMERMAN, Peter; (US)
Agent: SMITH, DeAnn F.; Foley Hoag LLP Seaport West 155 Seaport Blvd. Boston, MA 02210-2600 (US)
Priority Data:
61/831,894 06.06.2013 US
Title (EN) COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT PREVENTION, AND TREATMENT OF CANCER USING PD-L1 ISOFORMS
(FR) COMPOSITIONS ET PROCÉDÉS D'IDENTIFICATION, D'ÉVALUATION, DE PRÉVENTION ET DE TRAITEMENT DU CANCER EN UTILISANT DES ISOFORMES PD-L1
Abstract: front page image
(EN)The present invention relates to methods for identifying, assessing, preventing, and treating cancer (e.g., head, neck, and/or lung cancers in humans). A variety of PD-LI isoforni biomarkers are pro v ided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or acti vity of one or more of the biomarkers is associated with cancer status and indicates amenability to treatment or prevention by modulating PD-1 and/or PD-L! levels.
(FR)La présente invention concerne des procédés d'identification, d'évaluation, de prévention et de traitement du cancer (par exemple, les cancers de la tête, du cou et/ou du poumon chez les humains). Une variété de biomarqueurs d'isoforme PD-L1 sont fournis, les modifications du nombre de copies d'au moins un des biomarqueurs et/ou les modifications de la quantité, de la structure et/ou de l'activité d'un ou de plusieurs des biomarqueurs étant associées au statut du cancer et indiquant la possibilité de traitement et de prévention par modulation des niveaux de PD-1 et/ou de PD-L1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)