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1. (WO2014197369) COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT PREVENTION, AND TREATMENT OF CANCER USING PD-L1 ISOFORMS

Pub. No.:    WO/2014/197369    International Application No.:    PCT/US2014/040504
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Tue Jun 03 01:59:59 CEST 2014
IPC: G01N 33/50
Applicants: DANA-FARBER CANCER INSTITUTE, INC.
Inventors: HAMMERMAN, Peter
Title: COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT PREVENTION, AND TREATMENT OF CANCER USING PD-L1 ISOFORMS
Abstract:
The present invention relates to methods for identifying, assessing, preventing, and treating cancer (e.g., head, neck, and/or lung cancers in humans). A variety of PD-LI isoforni biomarkers are pro v ided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or acti vity of one or more of the biomarkers is associated with cancer status and indicates amenability to treatment or prevention by modulating PD-1 and/or PD-L! levels.