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1. (WO2014197240) METHODS AND DEVICES FOR STIMULATING AN IMMUNE RESPONSE USING NANOSECOND PULSED ELECTRIC FIELDS

Pub. No.:    WO/2014/197240    International Application No.:    PCT/US2014/039613
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Wed May 28 01:59:59 CEST 2014
IPC: A61N 1/32
Applicants: NANOBLATE CORPORATION
Inventors: NUCCITELLI, Richard Lee
NUCCITELLI, Pamela
LUM, Joanne
LUI, Kaying
ATHOS, Brian
KREIS, Mark
MALLON, Zachary
BERRIDGE, Jon
Title: METHODS AND DEVICES FOR STIMULATING AN IMMUNE RESPONSE USING NANOSECOND PULSED ELECTRIC FIELDS
Abstract:
Nanosecond pulsed electric field (nsPEF) treatments of a tumor are used to cause the tumor to express calreticulin and stimulate an immune response against the tumor and other tumors in a subject. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.