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1. (WO2014196795) MDCK-DERIVED CELL STRAIN SUSPENSION-CULTURED IN PROTEIN-FREE MEDIUM AND METHOD FOR PROLIFERATING VIRUS USING CELL STRAIN

Pub. No.:    WO/2014/196795    International Application No.:    PCT/KR2014/004949
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Wed Jun 04 01:59:59 CEST 2014
IPC: C12N 5/10
C12N 5/071
C12N 5/02
A61K 39/12
Applicants: MOGAM BIOTECHNOLOGY INSTITUTE
재단법인 목암생명공학연구소
Inventors: HWANG, Mihee
황미희
PARK, Kukjin
박국진
SHIN, Duckhyang
신덕향
LEE, Hyeon
이현
KIM, Sooin
김수인
CHO, Eunyoung
조은영
KIM, Misuk
김미숙
AHN, Dong Ho
안동호
Title: MDCK-DERIVED CELL STRAIN SUSPENSION-CULTURED IN PROTEIN-FREE MEDIUM AND METHOD FOR PROLIFERATING VIRUS USING CELL STRAIN
Abstract:
The present invention relates to a novel MDCK-derived cell strain capable of being suspension-cultured in a protein-free medium and a method for proliferating virus using the MDCK cell strain to produce a vaccine. The novel MDCK-derived cell strain according to the present invention exhibits high and uniform productivity with respect to various viruses, and has a low tumorigenic capacity while causing less viral antigenic variation, and thus can be useful in producing vaccine viruses.