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1. (WO2014196644) BENZOTHIOPHENE COMPOUND

Pub. No.:    WO/2014/196644    International Application No.:    PCT/JP2014/065141
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Sat Jun 07 01:59:59 CEST 2014
IPC: C07D 409/10
A61K 31/4025
A61K 31/4535
A61K 31/5377
A61K 31/551
A61P 19/02
A61P 21/00
A61P 25/04
A61P 29/00
A61P 43/00
C07D 413/10
Applicants: ASTELLAS PHARMA INC.
アステラス製薬株式会社
Inventors: ISHIHARA, Tsukasa
石原 司
IKEGAI, Kazuhiro
生貝 和弘
KURIWAKI, Ikumi
栗脇 生実
HISAMICHI, Hiroyuki
久道 弘幸
TAKESHITA, Nobuaki
竹下 暢昭
TAKEZAWA, Ryuichi
武沢 竜一
Title: BENZOTHIOPHENE COMPOUND
Abstract:
The inventors perfected the present invention as a result of a study into IK1 channel activators and a confirmation that a benzothiophene compound exhibits efficacy against visceral pain, inflammatory pain, osteoarthritic pain, neuropathic pain, or fibromyalgia. This compound, represented by formula (I), has IK1 channel activating action, and may be used as a drug to prevent or treat visceral pain, inflammatory pain, osteoarthritic pain, neuropathic pain, fibromyalgia, or the like. The IK1 channel activator may be used as a drug to prevent or treat inflammatory pain, osteoarthritic pain, neuropathic pain, or fibromyalgia.