WO2014195888 DUAL SELECTIVE PI3 DELTA AND GAMMA KINASE INHIBITORS

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Publication Number WO/2014/195888

Publication Date 11.12.2014

International Application No. PCT/IB2014/061954

International Filing Date 04.06.2014

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Applicants

RHIZEN PHARMACEUTICALS SA [CH]/[CH]

Inventors

VAKKALANKA, Swaroop K. V. S.
BHAVAR, Prashant K.
VISWANADHA, Srikant
BABU, Govindarajulu

Priority Data

2501/CHE/2013		07.06.2013		IN
5567/CHE/2013		03.12.2013		IN

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) DUAL SELECTIVE PI3 DELTA AND GAMMA KINASE INHIBITORS

(FR) INHIBITEURS BI-SÉLECTIFS DELTA ET GAMMA DES KINASES PI3

Abstract

(EN) The present invention relates to dual delta (δ) and gamma (γ) PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of Pi3K kinase mediated diseases or disorders with them.

(FR) La présente invention concerne des doubles modulateurs delta (δ) et gamma (γ) des protéines kinases PI3K, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et des méthodes qui permettent de traiter, de prévenir et/ou d'atténuer les effets de maladies ou de troubles dont la médiation est assurée par une kinase Pi3K au moyen de ceux-ci.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
473	Heterocyclic compounds containing purine ring systems
02	with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
04	two oxygen atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings
52	Purines, e.g. adenine

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
473	Heterocyclic compounds containing purine ring systems
02	with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
04	two oxygen atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings
52	Purines, e.g. adenine

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1. WO2014195888 - DUAL SELECTIVE PI3 DELTA AND GAMMA KINASE INHIBITORS