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1. (WO2014195803) CONTIGUOUS OVERLAPPING PEPTIDES FOR TREATMENT OF HOUSE DUST MITES ALLERGY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/195803 International Application No.: PCT/IB2014/001888
Publication Date: 11.12.2014 International Filing Date: 06.06.2014
IPC:
A61K 39/36 (2006.01) ,C07K 14/415 (2006.01) ,A61K 39/35 (2006.01) ,C07K 14/435 (2006.01) ,A61K 39/02 (2006.01) ,A61K 39/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
35
Allergens
36
from pollen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
415
from plants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
35
Allergens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
ANERGIS S.A. [CH/CH]; Route De La Corniche 9b CH-1066 Epalinges, CH
Inventors:
KETTNER, Alexander; CH
REYMOND, Christophe; CH
Agent:
ZWICKER, Jörk; ZSP Patentanwälte Radlkoferstrasse 2 81373 München, DE
Priority Data:
61/831,96106.06.2013US
Title (EN) CONTIGUOUS OVERLAPPING PEPTIDES FOR TREATMENT OF HOUSE DUST MITES ALLERGY
(FR) PEPTIDES CONTIGUS SE CHEVAUCHANT POUR LE TRAITEMENT D'UNE ALLERGIE AUX ACARIENS DE LA POUSSIÈRE
Abstract:
(EN) Contiguous overlapping peptides (COPs) for the treatment of allergic patients by Specific Immunotherapy (SIT) are provided from the sequence of the major allergens of house dust mites Der p 1 and Der p 2. Such peptides while providing all potential T cell epitopes are devoid of the three dimensional structure of the original allergen, therefore reducing their ability to bind IgE. As a result increased amounts of COPs can be administered per injection, therefore reducing both the number of injections and the length of the immunotherapy treatment.
(FR) L'invention concerne des peptides contigus se chevauchant (COP) pour le traitement de patients allergiques par immunothérapie spécifique (ITS) à partir des principaux allergènes des acariens de la poussière Der p 1 et Der p 2. Ces peptides, tout en apportant tous les épitopes potentiels associés aux lymphocytes T, sont dépourvus de la structure tridimensionnelle de l'allergène d'origine, ce qui réduit leur capacité à lier l'IgE. De ce fait, il est possible d'administrer des quantités plus importantes de COP par injection et donc de réduire tant le nombre d'injections que la durée du traitement par immunothérapie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)