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1. (WO2014195762) ANTIBACTERIAL POWDERS BASED ON ANIONIC SILICON OR TITANIUM DIOXIDE ADSORBED WITH PHARMACEUTICALLY ACTIVE CATIONS

Pub. No.:    WO/2014/195762    International Application No.:    PCT/IB2013/054647
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Fri Jun 07 01:59:59 CEST 2013
IPC: A61K 8/25
A61K 8/29
A61K 8/49
A61K 8/58
A61Q 11/00
A61K 9/16
A61K 33/38
A61L 15/46
Applicants: PAVIA FARMACEUTICI S.R.L.
Inventors: FERRARI, Massimo
Title: ANTIBACTERIAL POWDERS BASED ON ANIONIC SILICON OR TITANIUM DIOXIDE ADSORBED WITH PHARMACEUTICALLY ACTIVE CATIONS
Abstract:
The present invention relates to a dioxide silicon or titanium derivative of formula (I): (MO2)- (Am+) y, as active ingredient for the preparation of a composition having antibacterial properties useful, e.g. for topical administration. The dioxide derivatives of the present invention comprises anionic silica (SiO2)n- or anionic titanium dioxide particles (TiO2) n-, adsorbed with at least one cationic pharmaceutical active moiety (Am+), which may include, for instance, known antibacterial agents such as chlorexidine and the like. Furthermore, the invention relates to a composition for topical use, which may form an efficacious barrier against external microbes, substantially avoiding any infection on the affected skin.