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1. (WO2014195755) HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A KETAL GROUP

Pub. No.:    WO/2014/195755    International Application No.:    PCT/IB2013/001517
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Thu Jun 06 01:59:59 CEST 2013
IPC: C12N 15/11
A61K 9/107
A61K 47/48
Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors: BARTHELEMY, Philippe
OUMZIL, Khalid
ROCCHI, Palma
ACUNZO, Julie
Title: HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A KETAL GROUP
Abstract:
The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5' end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 19 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.