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1. (WO2014195692) AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/195692 International Application No.: PCT/GB2014/051693
Publication Date: 11.12.2014 International Filing Date: 03.06.2014
IPC:
C12N 7/00 (2006.01)
Applicants: THE PIRBRIGHT INSTITUTE[GB/GB]; Ash Road Pirbright Woking Surrey GU24 0NF, GB
Inventors: FIFE, Mark; GB
GIBSON, Mark; GB
Agent: HOLLIDAY, Louise; GB
Priority Data:
1310031.805.06.2013GB
Title (EN) AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION
(FR) CELLULES AVIAIRES POUR LA PRODUCTION AMÉLIORÉE DE VIRUS
Abstract:
(EN) The present Invention provides as avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM 1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3).
(FR) La présente invention concerne une cellule aviaire dans laquelle l'expression ou l'activité d'au moins l'un des gènes suivants, ou d'un homologue correspondant : IFITM 1 de poulet (SEQ ID No 1); IFITM2 de poulet (SEQ ID No 2) et IFITM3 de poulet (SEQ ID No 3) est réduite. L'invention concerne également des procédés permettant le passage de virus dans des cellules aviaires, des embryons et/ou des lignées de cellules aviaires dont l'expression d'un ou de plusieurs gènes IFITM est réduite et des procédés qui consistent à étudier la séquence d'au moins l'un des gènes suivants, ou d'un homologue correspondant : IFITM1 de poulet (SEQ ID No 1); IFITM2 de poulet (SEQ ID No 2) et IFITM3 de poulet (SEQ ID No 3).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)