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1. (WO2014195430) HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A KETAL GROUP
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/195430 International Application No.: PCT/EP2014/061755
Publication Date: 11.12.2014 International Filing Date: 05.06.2014
IPC:
C12N 15/11 (2006.01) ,A61K 9/107 (2006.01) ,A61K 47/48 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, Rue de Tolbiac F-75013 Paris, FR
UNIVERSITÉ DE BORDEAUX [FR/FR]; 35 Place Pey Berland F-33000 Bordeaux, FR
UNIVERSITE D'AIX-MARSEILLE [FR/FR]; Jardin du Pharo 58, boulevard Charles Livon F-13007 Marseille, FR
INSTITUT JEAN PAOLI & IRENE CALMETTES [FR/FR]; Centre Régional de Lutte Contre le Cancer 232 boulevard de Sainte-Marguerite F-13273 Marseille Cedex 9, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; 3, rue Michel Ange F-75016 Paris, FR
Inventors:
BARTHELEMY, Philippe; FR
OUMZIL, Khalid; FR
ROCCHI, Palma; FR
ACUNZO, Julie; FR
Agent:
DOMENEGO, Bertrand; Lavoix 2, place d'Estienne d'Orves F-75009 Paris, FR
Priority Data:
PCT/IB2013/00151705.06.2013IB
Title (EN) HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A KETAL GROUP
(FR) OLIGONUCLÉOTIDES ANTISENS MODIFIÉS POUR ÊTRE HYDROPHOBES COMPRENANT UN GROUPE CÉTAL
Abstract:
(EN) The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5' end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
(FR) Cette invention concerne un oligonucléotide modifié par substitution à son extrémité 3' ou 5' par un fragment comprenant au moins un groupe fonctionnel de type cétal, le carbone du cétal dudit groupe fonctionnel de type cétal portant deux chaînes hydrocarbonées saturées ou non, linéaires ou ramifiées comprenant de 1 à 22 atomes de carbone, et son utilisation en tant que médicament, en particulier son utilisation pour traiter le cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)