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1. (WO2014195405) CHARACTERIZATION OF COLISTIMETHATE SODIUM (CMS)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/195405    International Application No.:    PCT/EP2014/061690
Publication Date: 11.12.2014 International Filing Date: 05.06.2014
IPC:
B01D 15/16 (2006.01), B01D 15/32 (2006.01), C07K 7/62 (2006.01)
Applicants: XELLIA PHARMACEUTICALS APS [DK/DK]; Dalslandsgate 11 DK-2300 København S (DK)
Inventors: KØPPEN, Benny; (DK).
BENCIC, Nenad; (HR).
MELANDER, Claes; (SE)
Agent: ONSAGERS; P.O.Box 1813 Vika N-0123 Oslo (NO)
Priority Data:
61/832,345 07.06.2013 US
Title (EN) CHARACTERIZATION OF COLISTIMETHATE SODIUM (CMS)
(FR) CARACTÉRISATION DU COLISTIMÉTHATE DE SODIUM (CMS)
Abstract: front page image
(EN)The present invention regards a HPLC method useful for analyzing colistimethate sodium (CMS) or for the separation of CMS components. It consists in a HPLC method using a hydrophobic stationary phase and a mobile phase comprising an aqueous buffer and an organic solvent whose concentration in the mobile phase is increased during the elution. The aqueous buffer is preferably a phosphate buffer and the organic solvent preferably acetonitrile.
(FR)La présente invention porte sur un procédé de CLHP utile dans l'analyse du colistiméthate de sodium (CMS) ou dans la séparation des constituants du CMS. Elle consiste en un procédé de CLHP utilisant une phase stationnaire hydrophobe et une phase mobile comprenant un tampon aqueux et un solvant organique dont la concentration dans la phase mobile est accrue durant l'élution. Le tampon aqueux est de préférence un tampon phosphate et le solvant organique est de préférence l'acétonitrile.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)