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1. (WO2014195381) POLYPEPTIDES WITH PERMEASE ACTIVITY

Pub. No.:    WO/2014/195381    International Application No.:    PCT/EP2014/061640
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Thu Jun 05 01:59:59 CEST 2014
IPC: C07K 14/395
Applicants: DSM IP ASSETS B.V.
Inventors: KLAASSEN, Paul
DE WAAL, Paulus Petrus
DE JONG, René Marcel
Title: POLYPEPTIDES WITH PERMEASE ACTIVITY
Abstract:
The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the aminoacid at that position is replaced by an aminoacid that has a van der Waals volume of 80 to 138Å3 and a side chain hydrophobicity of 10 to 100 ∆tR.