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1. (WO2014195311) 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Pub. No.:    WO/2014/195311    International Application No.:    PCT/EP2014/061478
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Wed Jun 04 01:59:59 CEST 2014
IPC: C07D 487/04
A61K 31/4985
A61P 25/00
Applicants: JANSSEN PHARMACEUTICA NV
Inventors: VAN GOOL, Michiel, Luc, Maria
ALONSO-DE DIEGO, Sergio-Alvar
CID-NÚÑEZ, José, Maria
DELGADO-GONZÁLEZ, Óscar
DECORTE, Annelies, Marie, Antonius
MACDONALD, Gregor, James
MEGENS, Antonius, Adrianus, Hendrikus, Petrus
TRABANCO-SUÁREZ, Andrés, Avelino
GARCÍA-MOLINA, Aránzazu
ANDRÉS-GIL, José, Ignacio
Title: 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
Abstract:
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved, especially CNS disorders.