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1. (WO2014194826) THREE-CIRCLE FUSED-HETEROCYCLE NUCLEOSIDE PHOSPHORAMIDATE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/194826 International Application No.: PCT/CN2014/079165
Publication Date: 11.12.2014 International Filing Date: 04.06.2014
IPC:
C07H 19/10 (2006.01) ,C07H 1/00 (2006.01) ,A61K 31/7072 (2006.01) ,A61P 31/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1
Processes for the preparation of sugar derivatives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7068
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072
having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants: NANJING SANHOME PHARMACEUTICAL CO., LTD.[CN/CN]; 9 Huizhong Road, Nanjing Economic and Technological Development Zone Nanjing, Jiangsu 210038, CN
Inventors: WANG, Yong; CN
ZHAO, Liwen; CN
BI, Sheng; CN
GAO, Yiping; CN
WANG, Dezhong; CN
CHEN, Hongyan; CN
LIU, Yang; CN
ZHANG, Cang; CN
ZHANG, Wenping; CN
GUO, Xiao; CN
NAN, Yang; CN
Agent: NANJING ZHONGLIAN PATENT AGENCY CO.,LTD; 7 Floor, Wanda Business Building, No.129 Fuyuan Street, Jianye District Nanjing, Jiangsu 210017, CN
Priority Data:
201310225156.506.06.2013CN
Title (EN) THREE-CIRCLE FUSED-HETEROCYCLE NUCLEOSIDE PHOSPHORAMIDATE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
(FR) COMPOSÉ PHOSPHORAMIDATE DE NUCLÉOSIDE À TROIS HÉTÉROCYCLES FUSIONNÉS CIRCULAIREMENT, PROCÉDÉ DE PRÉPARATION ET APPLICATION
(ZH) 三环稠杂环类核苷氨基磷酸酯化合物、其制备方法及应用
Abstract:
(EN) The present invention provides a three-circle fused-heterocycle nucleoside phosphoramidate compound, a preparation method therefor, a composition containing the fused-heterocycle nucleoside phosphoramidate compound, and an application of the compound or composition serving as a medicine for curing the virus-infectious disease, and especially, an application of the compound or composition serving as a medicine for curing viral hepatitis.
(FR) La présente invention concerne un composé phosphoramidate de nucléoside à trois hétérocycles fusionnés circulairement, un procédé de préparation de celui-ci, une composition contenant le composé phosphoramidate de nucléoside à hétérocycles fusionnés, et une application du composé ou de la composition en tant que médicament pour traiter des maladies infectieuses virales, et en particulier, une application du composé ou de la composition en tant que médicament pour traiter l'hépatite virale.
(ZH) 本发明提供了一类三环稠杂环类核苷氨基磷酸酯化合物、其制备方法、含有该核苷氨基磷酸酯化合物的组合物,以及所述化合物或组合物作为病毒感染性疾病治疗药物的用途,特别是作为病毒性肝炎治疗药物的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)