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1. (WO2014194809) NEW COMPOUNDS HAVING TRIPLE ACTIVITIES OF THROMBOLYSIS, ANTITHROMBOTIC AND RADICAL SCAVENGING, AND SYNTHESIS, NANO-STRUCTURE AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/194809 International Application No.: PCT/CN2014/079098
Publication Date: 11.12.2014 International Filing Date: 03.06.2014
IPC:
C07K 5/117 (2006.01) ,A61K 38/07 (2006.01) ,A61P 7/02 (2006.01) ,A61P 39/06 (2006.01)
Applicants: SHANGHAI LUMOSA THERAPEUTICS CO., LTD.[CN/CN]; Room 3026, 3rd Floor, Building 1, No. 146 1st East Fute Road, Shanghai Pilot Free Trade Zone 200131, CN
Inventors: PENG, Shiqi; CN
ZHAO, Ming; CN
WU, Jianhui; CN
WANG, Yuji; CN
FENG, Qiqi; CN
Agent: BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD.; F16,Block A,Corporate Square,No.35 Jinrong Street Beijing 100033, CN
Priority Data:
201310225330.605.06.2013CN
Title (EN) NEW COMPOUNDS HAVING TRIPLE ACTIVITIES OF THROMBOLYSIS, ANTITHROMBOTIC AND RADICAL SCAVENGING, AND SYNTHESIS, NANO-STRUCTURE AND USE THEREOF
(FR) NOUVEAUX COMPOSÉS AYANT UNE TRIPLE ACTIVITÉ DE THROMBOLYSE, ANTITHROMBOTIQUE ET DE CAPTURE DES RADICAUX ET LEUR SYNTHÈSE, NANOSTRUCTURE ET UTILISATION
(ZH) 具有溶栓、抗栓和自由基清除三重活性的新型化合物、其合成、纳米结构和应用
Abstract: front page image
(EN) Provided in the present invention are new compounds having the triple activities of thrombolysis, antithrombotic and radical scavenging as represented by general formula (I), wherein T is a connecting arm having at least two groups for connection use, Q is a peptide having a thrombolysis activity, and R1 and R2 are C1-4alkyl, wherein R1 and R2 can be the same or different. Also provided in the present invention are the preparation method and use of the compound, and a pharmaceutical composition containing the compounds.
(FR) La présente invention a pour objet de nouveaux composés ayant une triple activité de thrombolyse, antithrombotique et de capture des radicaux, représentés par la formule générale (I), dans laquelle T représente un bras de liaison ayant au moins deux groupes destinés à être utilisés comme liaison, Q représente un peptide ayant une activité de thrombolyse et R1 et R2 représentent chacun un groupe alkyle en C1-4, R1 et R2 pouvant être identiques ou différents. La présente invention a également pour objet le procédé de préparation et l'utilisation du composé et une composition pharmaceutique contenant les composés.
(ZH) 本发明提供了具有溶栓、抗栓和自由基清除三重活性的化合物,其由通式I表示。其中,T为具有至少两个连接用基团的连接臂,Q为具溶栓活性的肽,R1和R2为C1-4垸基,R1和R2可相同或不同。本发明还提供了所述化合物的制备方法、用途以及包含所述化合物的药物组合物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)