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1. (WO2014194551) BIOSYNTHESIS GENE CLUSTER OF MARINACARBOLINES AND USE THEREOF

Pub. No.:    WO/2014/194551    International Application No.:    PCT/CN2013/079434
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Wed Jul 17 01:59:59 CEST 2013
IPC: C12N 15/11
C12N 15/52
C12N 9/00
C12P 17/18
Applicants: SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY,CHINESE ACADEMY OF SCIENCES
中国科学院南海海洋研究所
Inventors: JU, Jianhua
鞠建华
CHEN, Qi
陈奇
JI, Changtao
纪昌涛
Title: BIOSYNTHESIS GENE CLUSTER OF MARINACARBOLINES AND USE THEREOF
Abstract:
Disclosed are a biosynthesis gene cluster of marinacarbolines (MCBs) and a use thereof. The nucleotide sequence of the gene cluster is as shown by positions 1-4222 of SEQ ID NO. 1, and comprises three genes: a gene mcbA responsible for the synthesis of the amide linkage of the MCBs, a gene mcbB responsible for the Pictet-Spengler reaction of MCBs, and a gene mcbC responsible for the decarboxylation of the MCBs.