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|1. (WO2014194551) BIOSYNTHESIS GENE CLUSTER OF MARINACARBOLINES AND USE THEREOF|
|Applicants:||SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY,CHINESE ACADEMY OF SCIENCES
|Title:||BIOSYNTHESIS GENE CLUSTER OF MARINACARBOLINES AND USE THEREOF|
Disclosed are a biosynthesis gene cluster of marinacarbolines (MCBs) and a use thereof. The nucleotide sequence of the gene cluster is as shown by positions 1-4222 of SEQ ID NO. 1, and comprises three genes: a gene mcbA responsible for the synthesis of the amide linkage of the MCBs, a gene mcbB responsible for the Pictet-Spengler reaction of MCBs, and a gene mcbC responsible for the decarboxylation of the MCBs.