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1. (WO2014194362) PROCESS FOR PREPARING APOLIPOPROTEIN A-I (APO A-I)
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/194362 International Application No.: PCT/AU2014/000584
Publication Date: 11.12.2014 International Filing Date: 05.06.2014
IPC:
C07K 14/775 (2006.01) ,C07K 1/14 (2006.01) ,C07K 1/30 (2006.01) ,C07K 1/34 (2006.01) ,C07K 1/36 (2006.01) ,A61K 38/17 (2006.01) ,A61K 31/685 (2006.01) ,A61K 31/688 (2006.01) ,A61P 3/06 (2006.01)
Applicants: CSL LIMITED[AU/AU]; 45 Poplar Road Parkville, Victoria 3052, AU
Inventors: VUCICA, Yvonne; CH
WARREN, Gary Lee; US
Agent: FISHER ADAMS KELLY; Level 6, 175 Eagle Street Brisbane, QLD 4000, AU
Priority Data:
61/831,30405.06.2013US
Title (EN) PROCESS FOR PREPARING APOLIPOPROTEIN A-I (APO A-I)
(FR) PROCEDE POUR LA PREPARATION D'APOLIPOPROTEINE A-1 (APO A-1)
Abstract: front page image
(EN) The present invention relates to processes of obtaining Apo A-1 from an Apo A-1 containing protein fraction (A), comprising suspending- the Apo A-1 containing protein fraction (A) in a buffer solution (B), removing impurities from the suspension while keeping the Apo A- 1 proteins solubilized, followed by precipitating Apo A~ I from the suspension and collecting the Apo A-l precipitate. Apo A-I obtained by such processes, reconstituted HDL obtained from such Apo A-1, and pharmaceutical compositions comprising such Apo A-I and/or reconstituted HDL also are provided.
(FR) La présente invention porte sur un procédé d'obtention d'Apo A-1 à partir d'une fraction protéique (A) contenant Apo A-1, comprenant la mise en suspension de la fraction protéique (A) contenant Apo A-1 dans une solution tampon (B), l'élimination d'impuretés de la suspension, les protéines Apo A-1 étant simultanément maintenues solubilisées, suivies de la précipitation d'Apo A-1 dans la suspension et du recueil du précipité d'Apo A-1. L'invention porte également sur l'Apo A-1 obtenue par de tels procédés, sur de l'HDL reconstitué obtenu à partir d'une telle Apo A-1 et sur des compositions pharmaceutiques comprenant une telle Apo A-1 et/ou un tel HDL reconstitué.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)