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1. (WO2014194280) NOVEL SUICIDAL LSD1 INHIBITORS TARGETING SOX2-EXPRESSING CANCER CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/194280 International Application No.: PCT/US2014/040368
Publication Date: 04.12.2014 International Filing Date: 30.05.2014
IPC:
A61K 31/27 (2006.01)
Applicants: THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF NEVADA, LAS VEGAS[US/US]; 4505 S. Maryland Parkway Las Vegas, NV 89154, US
Inventors: ZHANG, Hui; US
Agent: SHORTELL, D. Brian; Ballard Sphar LLP 999 Peachtree Street Suite 1000 Atlanta, GA 30309, US
Priority Data:
61/828,74930.05.2013US
61/937,39407.02.2014US
Title (EN) NOVEL SUICIDAL LSD1 INHIBITORS TARGETING SOX2-EXPRESSING CANCER CELLS
(FR) NOUVEAUX INHIBITEURS SUICIDES DE LA LSD1 CIBLANT LES CELLULES CANCÉREUSES EXPRIMANT LE SOX2
Abstract:
(EN) Disclosed are inhibitors of lysine-specific demethylase I (LSD1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating cancers characterized by the presence of Sox2 using the compounds and compositions Also disclosed are methods of treating cancers characterized by the presence of Sox2 using inhibitors of LSD 1 and/or histone deacetylation I (HDAC1). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
(FR) La présente invention concerne des inhibiteurs de la déméthylase I spécifique de la lysine (LSD1); des procédés de synthèse permettant de fabriquer les composés; des compositions pharmaceutiques comprenant les composés; et des méthodes de traitement de cancers caractérisés par la présence de Sox2 en utilisant les composés et les compositions. L'invention concerne également des méthodes de traitement de cancers caractérisés par la présence de Sox2 en utilisant des inhibiteurs de la LSD1 et/ou de l'histone déacétylase I (HDAC1). Le présent abrégé se veut un outil de recherche dans le but d'explorer l'état de la technique et n'est pas censé limiter la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)