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1. (WO2014194160) AUTOMATED PERCENTAGE OF BREAST DENSITY MEASUREMENTS FOR FULL FIELD DIGITAL MAMMOGRAPHY

Pub. No.:    WO/2014/194160    International Application No.:    PCT/US2014/040140
Publication Date: Fri Dec 05 00:59:59 CET 2014 International Filing Date: Sat May 31 01:59:59 CEST 2014
IPC: G06K 9/00
Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: HEINE, John, J.
SELLERS, Thomas, A.
VACHON, Celine, M.
FOWLER, Erin, E.
Title: AUTOMATED PERCENTAGE OF BREAST DENSITY MEASUREMENTS FOR FULL FIELD DIGITAL MAMMOGRAPHY
Abstract:
An automated percentage of breast density measure (PDa ) that analyzes signal dependent noise (SDN) based on a wavelet expansion using full field digital mammography (FFDM). A matched case-control dataset is used with images acquired from a specific direct x-ray capture FFDM system. PDa is applied to the raw and clinical display representation images. Transforming (pixel mapping) of the raw image to another representation (raw-transformed) is performed using differential evolution optimization and investigated the influence of lowering the native spatial resolution of the image by a one-half. When controlling for body mass index, the quartile specific ORs for the associations of PDa with breast cancer varied with representation and resolution. PDa is a valid automated breast density measurement for a specific FFDM technology and compares well against PD (operator-assisted or the standard) when applied to either the raw-transformed or clinical display images from this FFDM technology.