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1. (WO2014194030) CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS

Pub. No.:    WO/2014/194030    International Application No.:    PCT/US2014/039919
Publication Date: Fri Dec 05 00:59:59 CET 2014 International Filing Date: Fri May 30 01:59:59 CEST 2014
IPC: A61K 47/48
A61P 35/00
Applicants: IMMUNOGEN, INC.
Inventors: WIDDISON, Wayne, C.
CHARI, Ravi, V.J.
Title: CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS
Abstract:
The invention provides a branched linker compound with reactive moieties for forming covalent bonds with multiple cytotoxic agents (drugs) and/or a cell-binding agent (CBA); a cytotoxic compound comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; a modified cell-binding agent comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.