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Machine translation
1. (WO2014193951) BET INHIBITION THERAPY FOR HEART DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/193951    International Application No.:    PCT/US2014/039790
Publication Date: 04.12.2014 International Filing Date: 28.05.2014
IPC:
A61K 31/496 (2006.01), C07D 237/04 (2006.01), C07D 413/04 (2006.01)
Applicants: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Boston, MA 02215 (US).
CASE WESTERN RESERVE UNIVERSITY [US/US]; Technology Transfer Office 10900 Euclid Avenue, Sears 666 Cleveland, OH 44106 (US).
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 101 Huntington Avenue 4th Floor Research Ventures & Licensing Boston, MA 02115 (US)
Inventors: HALDAR, Saptarsi, M.; (US).
BRADNER, James, E.; (US).
BROWN, Jonathan, D.; (US)
Agent: HOLLOWAY, Minita, G.; (US)
Priority Data:
61/931,062 24.01.2014 US
61/828,166 28.05.2013 US
Title (EN) BET INHIBITION THERAPY FOR HEART DISEASE
(FR) THÉRAPIE PAR INHIBITION DE BET POUR UNE CARDIOPATHIE
Abstract: front page image
(EN)Method for treating cardiac diseases using BET inhibitors including JQ1 are provided. Methods for treating cardiac hypertrophy, method for treating heart failure not arising from inflammation, methods for treating myocardial infarction, methods for cardioprotection and methods for inhibiting restenosis are described herein. The methods involve the use of effective amounts of BET inhibitors such as JQ1.
(FR)La présente invention concerne un procédé de traitement de cardiopathies en utilisant des inhibiteurs de BET y compris JQ1. La présente invention concerne des procédés de traitement de l'hypertrophie cardiaque, des procédés de traitement d'une insuffisance cardiaque qui n'est pas liée à une inflammation, des procédés de traitement d'un infarctus du myocarde, des procédés de cardioprotection et des procédés d'inhibition d'une resténose. Les procédés impliquent l'utilisation de quantités efficaces d'inhibiteurs de BET tels que JQ1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)