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1. (WO2014193898) COMBINATION THERAPIES FOR CANCER

Pub. No.:    WO/2014/193898    International Application No.:    PCT/US2014/039686
Publication Date: Fri Dec 05 00:59:59 CET 2014 International Filing Date: Thu May 29 01:59:59 CEST 2014
IPC: A61K 31/506
C07D 413/12
A61K 31/519
A61P 35/00
Applicants: MERCK SHARP & DOHME CORP.
GLAXOSMITHKLINE LLC
HOOS, Axel
ORFORD, Keith, W.
CHUN, Patrick
SRIRAM, Venkataraman
PINHEIRO, Elaine, M.
EBBINGHAUS, Scot, W.
Inventors: HOOS, Axel
ORFORD, Keith, W.
CHUN, Patrick
SRIRAM, Venkataraman
PINHEIRO, Elaine, M.
EBBINGHAUS, Scot, W.
Title: COMBINATION THERAPIES FOR CANCER
Abstract:
A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and a PD-1 antagonist; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or immune modulation through PD-1 is beneficial, e.g., cancer.