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1. (WO2014193652) NOVEL N-3 IMMUNORESOLVENTS: STRUCTURES AND ACTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/193652 International Application No.: PCT/US2014/037969
Publication Date: 04.12.2014 International Filing Date: 14.05.2014
Chapter 2 Demand Filed: 27.03.2015
IPC:
A61K 31/202 (2006.01)
Applicants: THE BRIGHAM & WOMEN'S HOSPITAL INC.[US/US]; 101 Huntington Avenue, 4th Floor Boston, Massachusetts 02199-8001, US
Inventors: SERHAN, Charles N.; US
DALLI, Jesmond; US
Agent: CHRISTENSEN, Douglas J.; Christensen Fonder P.A. 33 South Sixth Street Suite 3950 Minneapolis, MN 55402, US
Priority Data:
61/829,06430.05.2013US
Title (EN) NOVEL N-3 IMMUNORESOLVENTS: STRUCTURES AND ACTIONS
(FR) NOUVEAUX IMMUNORÉSOLVANTS N-3: STRUCTURES ET ACTIONS
Abstract: front page image
(EN) The invention describes novel mono-hydroxy, di-hydroxy and tri-hydroxy docosapentaenoic acid (DPA) analogues, their preparation, isolation, identification, purification and uses thereof. Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidbmics and in vivo systems, endogenous n-3 docosapentaenoic (DP A) acid is converted during inflammation-resolution in mice and by human leukocytes to novel n-3 products congenerous to D-series resolvins (Rv), protectins (PD) and maresins (MaR), termed specialized pro-resolving mediators (SPM). The new n-3 DPA structures include 7,8,17-trihydroxy-9,11,13,15E, 19Zdocosapentaenoic acid (RvD1n_3 DPA), 7, 14-dihydroxy-8, 10, 12, 16Z, 19Z-docosapentaenoic acid (MaR1n_3 DPA) and related bioactive products.
(FR) L'invention concerne de nouveaux analogues de l'acide docosapentaénoïque (DPA) mono-hydroxy, di-hydroxy et tri-hydroxy, leur préparation, leur isolement, leur identification, leur purification et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)