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1. (WO2014193173) IGG4 FC FRAGMENT COMPRISING MODIFIED HINGE REGION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/193173 International Application No.: PCT/KR2014/004799
Publication Date: 04.12.2014 International Filing Date: 29.05.2014
IPC:
C07K 7/08 (2006.01) ,C12N 15/13 (2006.01) ,C12N 15/63 (2006.01) ,A61K 47/42 (2006.01)
Applicants: HANMI PHARM. CO., LTD.[KR/KR]; 214, Muha-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 445-958, KR
Inventors: JUNG, Sung Youb; KR
HUH, Yong Ho; KR
PARK, Sung Hee; KR
LEE, Jong Soo; KR
CHOI, In Young; KR
Agent: SON, Min; (Hanol Intellectual Property & Law) STX R&D Center, 6th Floor, 163, YangJaeCheon-ro, Gangnam-gu, Seoul 135-855, KR
Priority Data:
10-2013-006302931.05.2013KR
Title (EN) IGG4 FC FRAGMENT COMPRISING MODIFIED HINGE REGION
(FR) FRAGMENT FC D'IGG4 COMPRENANT UNE RÉGION CHARNIÈRE MODIFIÉE
(KO) 변이된 힌지 영역을 포함하는 IGG4 FC 단편
Abstract: front page image
(EN) The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. The combination of an arbitrary drug and the modified IgG4 Fc fragment of the present invention minimizes the effector function by the IgG4 Fc, and the chain exchange with in vivo IgG, and can maintain the in vivo activity of a drug conjugate and improve the in vivo extended release thereof.
(FR) La présente invention porte sur un fragment Fc d'IgG4 modifié utile en tant que vecteur de médicament. L'association d'un médicament arbitraire et du fragment Fc d'IgG4 modifié selon la présente invention réduit au minimum la fonction effectrice par le Fc d'IgG4 et l'échange de chaîne avec une IgG in vivo et permet de maintenir l'activité in vivo d'un conjugué avec un médicament et d'améliorer sa libération prolongée in vivo.
(KO) 본 발명은 약물의 캐리어로서 유용한 변이된 IgG4 Fc 단편에 관한 것으로서, 본 발명의 변이된 IgG4 Fc 단편을 임의의 약물과 결합시킬 경우, IgG4 Fc에 의한 이펙터 기능 및 생체내 IgG와의 사슬교환을 최소화 하며 약물 결합체의 생체내 활성 유지 및 생체내 지속성을 향상시킬 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)