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1. (WO2014193016) MUCUS LAYER-ADHESIVE POLY Γ-GLUTAMIC ACID NANOMICELLES AND DRUG DELIVERY SYSTEM USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/193016 International Application No.: PCT/KR2013/004927
Publication Date: 04.12.2014 International Filing Date: 04.06.2013
IPC:
A61K 9/127 (2006.01) ,A61K 47/30 (2006.01) ,A61K 47/48 (2006.01)
Applicants: BIOLEADERS CORPORATION[KR/KR]; 559, Yongsan-dong Yuseong-gu Daejeon 305-500, KR
THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY[KR/KR]; CHUNGNAM NATIONAL UNIVERSITY, 220, Kung-dong Yuseong-gu Deajeon 305-764, KR
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY[KR/KR]; 52 Oun-dong Yuseong-gu Daejeon 305-333, KR
KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION[KR/KR]; KOOKMIN UNIVERSITY, 861-1 Jeongneung-dong, Seongbuk-gu Seoul 136-702, KR
Inventors: CHOI, Jae-Chul; KR
LIM, Yong Taik; KR
POO, Haryoung; KR
SUNG, Moon-Hee; KR
Agent: LEE, Cheo young; 11th, Yeosam Bldg., 648-23 Yeoksam-dong, Gangnam-gu Seoul 135-080, KR
Priority Data:
10-2013-006273431.05.2013KR
Title (EN) MUCUS LAYER-ADHESIVE POLY Γ-GLUTAMIC ACID NANOMICELLES AND DRUG DELIVERY SYSTEM USING SAME
(FR) NANOMICELLES D'ACIDE POLY-Γ-GLUTAMIQUE À COUCHE ADHÉSIVE DE MUCUS ET SYSTÈME D'ADMINISTRATION DE MÉDICAMENT À L'AIDE DE CELLES-CI
(KO) 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
Abstract: front page image
(EN) The present invention relates to nanomicelles comprising a complex of a poly γ-glutamic acid of which a part of the carboxylic group is substituted by an amine group and an oleophilic compound and, more specifically, to nanomicelles comprising a complex of a poly γ-glutamic acid of which a part of the carboxylic group is substituted by an amine group and an oleophilic compound, a method for producing the same, and a drug delivery system using mucus layer-adhesive properties of the nanomicelles. According to the present invention, when the nanomicelles drug delivery system on the basis of the poly γ-glutamic acid, which is a biogenous natural polymer, is utilized in the field of drug delivery to a mucus layer region, the nanomicelles drug delivery system can improve biostability and effectiveness of a drug.
(FR) La présente invention concerne des nanomicelles comprenant un complexe d'un acide poly-γ-glutamique dont une partie du groupe carboxylique est substituée par un groupe amine et un composé oléophile et, plus spécifiquement, des nanomicelles comprenant un complexe d'un acide poly-γ-glutamique dont une partie du groupe carboxylique est substituée par un groupe amine et un composé oléophile, leur procédé de production, et un système d'administration de médicament utilisant des propriétés adhésives de couche de mucus des nanomicelles. Selon la présente invention, lorsque le système d'administration de médicament de nanomicelles, sur la base de l'acide poly-γ-glutamique, qui est un polymère naturel biogène, est utilisé pour l'administration de médicament à une région de couche de mucus, le système d'administration de médicament de nanomicelles peut améliorer la biostabilité et l'efficacité d'un médicament.
(KO) 본 발명은 카르복실기 일부가 아민기로 치환된 폴리감마글루탐산과 친유성 화합물의 복합체로 구성된 나노마이셀에 관한 것으로, 더욱 자세하게는 카르복실기 일부가 아민기로 치환된 폴리감마글루탐산과 친유성 화합물의 복합체로 구성된 나노마이셀 및 이의 제조방법과 상기 나노마이셀의 점막 점착특성을 이용한 약물전달체에 관한 것이다. 본 발명에 따른 생체 유래 천연고분자인 폴리감마글루탐산을 기반으로 한 나노마이셀 약물전달체를 점막 부위의 약물전달 분야에 활용함으로써, 약물의 생체 안정성 및 유효성 등을 향상시킬 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)