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1. (WO2014192923) METHOD FOR LIBERATING AND LABELING MODIFICATION GROUP, KIT FOR SAID METHOD, METHOD FOR ANALYSIS OF MODIFICATION GROUP, KIT FOR ANALYSIS, AND METHOD FOR LABELING FREE SUGAR CHAIN

Pub. No.:    WO/2014/192923    International Application No.:    PCT/JP2014/064436
Publication Date: Fri Dec 05 00:59:59 CET 2014 International Filing Date: Sat May 31 01:59:59 CEST 2014
IPC: G01N 33/58
A61K 38/00
G01N 33/66
Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
国立大学法人北海道大学
Inventors: SHINOHARA Yasuro
篠原 康郎
FURUKAWA Jun-ichi
古川 潤一
Title: METHOD FOR LIBERATING AND LABELING MODIFICATION GROUP, KIT FOR SAID METHOD, METHOD FOR ANALYSIS OF MODIFICATION GROUP, KIT FOR ANALYSIS, AND METHOD FOR LABELING FREE SUGAR CHAIN
Abstract:
A method for liberating a modification group from at least one of the serine residues and threonine residues of a modified glycoprotein contained in a sample and labeling the modification group, the method including a step in which a solution having a pH of 6.0-10.0 and containing a modified glycoprotein and a labeling agent that is at least one of pyrazolone derivatives, isoxazolone derivatives, hydantoin derivatives, rhodanine derivatives, and maleimide derivatives is irradiated with microwaves.