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1. (WO2014192202) RECOMBINANT PROTEIN CAPABLE OF BONDING SPECIFICALLY AND QUICKLY TO TROPONIN I FROM HUMAN MYOCARDIUM
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/192202 International Application No.: PCT/JP2014/001219
Publication Date: 04.12.2014 International Filing Date: 05.03.2014
IPC:
C07K 16/18 (2006.01) ,G01N 33/53 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
パナソニックヘルスケア株式会社 PANASONIC HEALTHCARE CO., LTD. [JP/JP]; 愛媛県東温市南方2131番地1 2131-1, Minamigata, Toon-shi, Ehime 7910395, JP
Inventors:
福永 淳 FUKUNAGA, Atsushi; null
Agent:
鮫島 睦 SAMEJIMA, Mutsumi; 大阪府大阪市北区角田町8番1号梅田阪急ビルオフィスタワー青山特許事務所 AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower, 8-1, Kakuda-cho, Kita-ku, Osaka-shi, Osaka 5300017, JP
Priority Data:
2013-11260529.05.2013JP
Title (EN) RECOMBINANT PROTEIN CAPABLE OF BONDING SPECIFICALLY AND QUICKLY TO TROPONIN I FROM HUMAN MYOCARDIUM
(FR) PROTÉINE RECOMBINÉE CAPABLE DE SE LIER DE FAÇON SPÉCIFIQUE ET RAPIDE À LA TROPONINE I DU TISSU MYOCARDIQUE HUMAIN
(JA) ヒト心筋由来トロポニンIに特異的にかつ速やかに結合できる組み換えタンパク質
Abstract:
(EN) Provided is a recombinant protein which is capable of bonding specifically and quickly to troponin I from human myocardium. In particular, the present invention provides a recombinant protein which is capable of bonding specifically and quickly to troponin I from human myocardium, the recombinant protein comprising a light chain variable region composed of an amino acid sequence represented by SEQ ID NO. 63 and a heavy chain variable region composed of an amino acid sequence represented by SEQ ID NO. 65. The present invention also provides a method for bonding this recombinant protein to troponin I from human myocardium, the method comprising a step (a) of preparing the recombinant protein and a step (b) of bringing the troponin I from human myocardium in contact with the recombinant protein and bonding the recombinant protein to the troponin I from human myocardium.
(FR) La présente invention concerne une protéine recombinée capable de se lier de façon spécifique et rapide à la troponine I du tissu myocardique humain. La présente invention concerne, en particulier, une protéine recombinée capable de se lier de façon spécifique et rapide à la troponine I du tissu myocardique humain, ladite protéine recombinée comportant une région variable de chaîne légère constituée d'une séquence d'acides aminés représentée par SEQ ID NO. 63 et une région variable de chaîne lourde constituée d'une séquence d'acides aminés représentée par SEQ ID NO. 65. La présente invention concerne également un procédé de liaison de ladite protéine recombinée à la troponine I du tissu myocardique humain, ledit procédé comprenant une étape (a) consistant à préparer ladite protéine recombinée et une étape (b) consistant à amener la troponine I du tissu myocardique humain en contact avec la protéine recombinée et à lier ladite protéine recombinée à la troponine I du tissu myocardique humain.
(JA)  本発明は、ヒト心筋由来トロポニンIに特異的にかつ速やかに結合できる組み換えタンパク質を提供する。特に、本発明は、ヒト心筋由来トロポニンIに特異的にかつ速やかに結合できる組み換えタンパク質であって、配列番号:63によって表されるアミノ酸配列からなる軽鎖可変領域;および配列番号:65によって表されるアミノ酸配列からなる重鎖可変領域を含む、組み換えタンパク質を提供する。本発明はまた、本発明の組み換えタンパク質をヒト心筋由来のトロポニンIに結合させる方法であって、前記組み換えタンパク質を用意する工程(a);および前記組み換えタンパク質に前記ヒト心筋由来のトロポニンIを接触させ、前記組み換えタンパク質を前記ヒト心筋由来のトロポニンIに結合させる工程(b)を含む方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)