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1. (WO2014191920) N-{3-[3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-PHENYLAMINO)-6,8-DIMETHYL-2,4,7-TRIOXO-3,4,6,7-TETRAHYDRO-2HP YRIDO[4,3-D]PYRIMIDIN-1 -YL]PHENYL}ACETAMIDE FOR USE IN THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/191920 International Application No.: PCT/IB2014/061757
Publication Date: 04.12.2014 International Filing Date: 27.05.2014
IPC:
A61K 31/519 (2006.01) ,A61K 35/00 (2006.01) ,A61K 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
02
from inanimate materials
04
Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate, e.g. Ichthyol
Applicants: NOVARTIS AG[CH/CH]; Lichtstrasse 35 4056 Basel, CH
Inventors: BEHBAHANI, Roya; US
HAMID, Mohammed R.; US
OUELLET, Daniele; US
PATEL, Kiran; US
ROGAN, Debra Ann; US
RICHARDS, Eric Michael; US
STREIT, Michael R.; US
Priority Data:
61/827,94028.05.2013US
Title (EN) N-{3-[3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-PHENYLAMINO)-6,8-DIMETHYL-2,4,7-TRIOXO-3,4,6,7-TETRAHYDRO-2HP YRIDO[4,3-D]PYRIMIDIN-1 -YL]PHENYL}ACETAMIDE FOR USE IN THE TREATMENT OF CANCER
(FR) N-{3-[3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-PHENYLAMINO)-6,8-DIMETHYL-2,4,7-TRIOXO-3,4,6,7-TETRAHYDRO-2HP YRIDO[4,3-D]PYRIMIDIN-1 -YL]PHENYL}ACETAMIDE EN VUE D'UNE UTILISATION DANS LE TRAITEMENT DU CANCER
Abstract:
(EN) Invented are methods for treating cancer in a human in need thereof which comprises the administration of a therapeutically effective amount of N-{3-[3-cyclopropyl- 5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H- pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a salt or solvate thereof, to such human. Also invented are methods of treating cancer in a human in need thereof which comprises the administration of a therapeutically effective amount of N-{3-[3-cyclopropyl-5-(2-fluoro- 4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3- d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide to such human.
(FR) L'invention concerne des méthodes de traitement du cancer chez un être humain en ayant besoin qui comprend l'administration d'une quantité thérapeutiquement efficace de N-{3-[3-cyclopropyl- 5-(2-fluoro-4-iodo-phénylamino)-6,8-diméthyl-2,4,7-trioxo-3,4,6,7-tétrahydro-2H- pyrido[4,3-d]pyrimidin-1-yl]phényl}acétamide ou d'un sel ou solvate de celui-ci à un cet être humain. L'invention concerne également des méthodes de traitement du cancer chez un être humain en ayant besoin qui comprend l'administration d'une quantité thérapeutiquement efficace de N-{3-[3-cyclopropyl-5-(2-fluoro- 4-iodo-phénylamino)-6,8-diméthyl-2,4,7-trioxo-3,4,6,7-tétrahydro-2H-pyrido[4,3- d]pyrimidin-1-yl]phényl}acétamide diméthyl sulfoxyde à cet être humain.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)