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1. (WO2014191911) PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/191911    International Application No.:    PCT/IB2014/061743
Publication Date: 04.12.2014 International Filing Date: 27.05.2014
IPC:
C07D 487/04 (2006.01), A61K 31/506 (2006.01), A61K 31/444 (2006.01), A61K 31/4439 (2006.01), A61P 35/00 (2006.01), A61P 31/00 (2006.01), A61P 3/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BLANK, Jutta [DE/CH]; (CH) (US only).
COTESTA, Simona [IT/CH]; (CH) (US only).
GUAGNANO, Vito [IT/CH]; (CH) (US only).
RUEEGER, Heinrich [CH/CH]; (CH) (US only)
Inventors: BLANK, Jutta; (CH).
COTESTA, Simona; (CH).
GUAGNANO, Vito; (CH).
RUEEGER, Heinrich; (CH)
Common
Representative:
NOVARTIS AG; Lichtstrasse 35 CH-4056 Basel (CH)
Priority Data:
13169448.1 28.05.2013 EP
Title (EN) PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
(FR) DÉRIVÉS DE PYRAZOLO-PYRROLIDIN-4-ONE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIE
Abstract: front page image
(EN)The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the pyrazolo-pyrrolidin-4-one derivatives, and their use as BET inhibitors for the treatment of conditions or diseases such as cancer. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
(FR)La présente invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci; un procédé de fabrication de dérivés de pyrazolo-pyrrolidin-4-one, et leurs utilisations en tant qu'inhibiteurs BET pour le traitement d'états pathologiques ou de maladies comme le cancer. La présente invention concerne également une combinaison d'agents pharmacologiquement actifs et une composition pharmaceutique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)