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1. (WO2014191737) HETEROCYCLIC COMPOUNDS AS HEDGEHOG SIGNALING PATHWAY INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/191737    International Application No.:    PCT/GB2014/051623
Publication Date: 04.12.2014 International Filing Date: 28.05.2014
Chapter 2 Demand Filed:    17.03.2015    
IPC:
C07D 401/14 (2006.01), C07D 401/04 (2006.01), C07D 403/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), A61K 31/501 (2006.01), A61K 31/502 (2006.01), A61K 31/5025 (2006.01), A61P 35/00 (2006.01)
Applicants: REDX PHARMA PLC [GB/GB]; Floor 9, Lowry House 17 Marble Street Manchester, Greater Manchester M2 3AW (GB)
Inventors: ARMER, Richard; (GB).
BINGHAM, Matilda; (GB).
BHAMRA, Inder; (GB).
MCCARROLL, Andrew; (GB)
Agent: HGF LIMITED; Belgrave Hall Belgrave Street Leeds Yorkshire LS2 8DD (GB)
Priority Data:
1309508.8 28.05.2013 GB
Title (EN) HETEROCYCLIC COMPOUNDS AS HEDGEHOG SIGNALING PATHWAY INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS COMME INHIBITEURS DE LA VOIE DE SIGNALISATION HEDGEHOG
Abstract: front page image
(EN)This invention relates to novel compounds of formula (I). The compounds of the invention are hedgehog pathway antagonists. Specifically, the compounds of the invention are useful as Smoothened (SMO) inhibitors. The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of the Hedgehog pathway and SMO, for example cancer.
(FR)L'invention concerne de nouveaux composés de formule (I). Les composés de l'invention sont des antagonistes de la voie Hedgehog. Les composés de l'invention sont utiles en particulier en tant qu'inhibiteurs de Smoothened (SMO). L'invention concerne également l'utilisation des composés pour le traitement d'états pouvant être traités par inhibition de la voie Hedgehog et de SMO, tel le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)