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1. (WO2014191527) A LAGLIDADG HOMING ENDONUCLEASE CLEAVING THE T CELL RECEPTOR ALPHA GENE AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/191527 International Application No.: PCT/EP2014/061189
Publication Date: 04.12.2014 International Filing Date: 28.05.2014
IPC:
C12N 9/22 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
22
Ribonucleases
Applicants:
CELLECTIS [FR/FR]; 8 Rue de la Croix Jarry F-75013 Paris, FR
PREGENEN INC. [US/US]; 454 North 34th Street Seattle, Washington 98103, US
Inventors:
ASTRAKHAN, Alexander; US
JARJOUR, Jordan; US
Agent:
ZACCO DENMARK A/S; Arne Jacobsens Allé 15 DK-2300 Copenhagen S, DK
Priority Data:
PA 2013 7030331.05.2013DK
Title (EN) A LAGLIDADG HOMING ENDONUCLEASE CLEAVING THE T CELL RECEPTOR ALPHA GENE AND USES THEREOF
(FR) ENDONUCLÉASE DE HOMING DE LA FAMILLE LAGLIDADG CLIVANT LE GÈNE ALPHA DU RÉCEPTEUR AUX LYMPHOCYTES T, ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHEs. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefore are also provided.
(FR) L'invention concerne des compositions destinées à inactiver le gène alpha du récepteur aux lymphocytes T (TCR) humain, contenant des endonucléases de homing de la famille LAGLIDADG (LHEs) modifiées et leurs dérivés, en particulier issus d'éléments de la sous-famille \-Onul des LHE. L'invention concerne également des polynucléotides codant ces endonucléases, des vecteurs contenant ces polynucléotides, des cellules contenant ces endonucléases ou ayant été traitées au moyen de celles-ci, ainsi que des compositions thérapeutiques associées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)