WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2014191467) FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/191467    International Application No.:    PCT/EP2014/061082
Publication Date: 04.12.2014 International Filing Date: 28.05.2014
IPC:
A61K 49/00 (2006.01), A61K 9/51 (2006.01), A61K 9/107 (2006.01)
Applicants: BRACCO IMAGING SPA [IT/IT]; Via Egidio Folli, 50 Milano I-20134 Milano (IT)
Inventors: GHIANI, Simona; (IT).
MAIOCCHI, Alessandro; (IT).
CAMINITI, Lara; (IT).
MIRAGOLI, Luigi; (IT)
Agent: MERLI, Silvia; (IT)
Priority Data:
13169851.6 30.05.2013 EP
Title (EN) FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF
(FR) COMPOSITION DE NANOPARTICULES LIPIDES SOLIDES FLUORESCENTES ET SA PRÉPARATION
Abstract: front page image
(EN)The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and /or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
(FR)La présente invention concerne une nanoparticule lipide solide (SLN) comprenant : a) un noyau lipide solide comprenant au moins un glycéride et/ou au moins un acide gras; b) un mélange de composants amphiphiles formant une enveloppe autour dudit noyau a); c) un complexe alcalino-terreux avec un composé de formule I et/ou II; d) au moins un colorant fluorescent choisi parmi : un colorant fluorescent de cyanine et/ou un composé polyéthérocyclique choisi parmi : des dérivés de coumarine, pyrano, quinoléine, pyranoquinoléine, indole et pyranoindole sous forme acide ou un sel pharmaceutiquement acceptable de ceux-ci. Ces nanoparticules permettent une demi-vie prolongée dans la circulation sanguine, montrent une photostabilité accrue et un signal de fluorescence amélioré. Le colorant est préservé de la dégradation et améliore le rendement quantique fluorescent.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)