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1. (WO2014191396) TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE

Pub. No.:    WO/2014/191396    International Application No.:    PCT/EP2014/060925
Publication Date: Fri Dec 05 00:59:59 CET 2014 International Filing Date: Wed May 28 01:59:59 CEST 2014
IPC: A61K 9/22
A61K 9/24
A61K 31/167
A61K 31/485
A61P 29/00
A61P 25/04
Applicants: GRÜNENTHAL GMBH
Inventors: BARNSCHEID, Lutz
GEISSLER, Anja
SCHWIER, Sebastian
DENKER, Jana
WENING, Klaus
STRAUB, Stefanie
Title: TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE
Abstract:
The invention relates to a pharmaceutical dosage form comprising: (i) at least one formed segment (S1), which contains a first pharmacologically active ingredient (A1) and provides prolonged release thereof, and (ii) at least one further segment (S2), which contains a second pharmacologically active ingredient (A2) and provides immediate release thereof, wherein the at least one formed segment (S1) exhibits a higher breaking strength than the at least one further segment (S2) and the at least one formed segment (S1) exhibits a breaking strength of more than 500 N.