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1. (WO2014190914) MATERIALS AND METHODS FOR TREATMENT OF LIVER CANCER BACKGROUND OF THE INVENTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/190914    International Application No.:    PCT/CN2014/078740
Publication Date: 04.12.2014 International Filing Date: 29.05.2014
Chapter 2 Demand Filed:    12.01.2015    
IPC:
A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: THE UNIVERSITY OF HONG KONG [CN/CN]; Pokfulam Road Hong Kong (CN)
Inventors: CHEUNG, Siu Tim; (CN).
CHEUNG, Fung Yi; (CN).
FAN, Sheung Tat; (CN)
Agent: CHINA PATENT AGENT (H.K.) LTD.; 22/F., Great Eagle Center, 23 Harbour Road, Wanchai Hong Kong (CN)
Priority Data:
61/829,027 30.05.2013 US
Title (EN) MATERIALS AND METHODS FOR TREATMENT OF LIVER CANCER BACKGROUND OF THE INVENTION
(FR) MATÉRIAUX ET MÉTHODES POUR LE TRAITEMENT DU CANCER DU FOIE
Abstract: front page image
(EN)Granulin-epithelin precursor (GEP), a pluripotent growth factor, is a hepatic oncofetal protein defining a cancer stem cell (CSC) population in liver cancer. The present invention provides the use of GEP inhibitors (including anti-GEP antibody) for inhibiting immune evasion by liver cancer cells and for eliminating liver cancer stem cells.
(FR)Le précurseur de granuline-épithéline (GEP), un facteur de croissance pluripotent, est une protéine oncofoetale hépatique qui définit une population de cellules souches cancéreuses (CSC) dans le cancer du foie. La présente invention concerne l'utilisation d'inhibiteurs de GEP (notamment des anticorps anti-GEP) qui permettent d'inhiber l'évasion immunitaire par des cellules cancéreuses hépatiques, et l'élimination de cellules souches du cancer du foie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)