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1. (WO2014190305) ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/190305    International Application No.:    PCT/US2014/039420
Publication Date: 27.11.2014 International Filing Date: 23.05.2014
IPC:
A61K 39/395 (2006.01), G01N 33/53 (2006.01), C07H 21/00 (2006.01)
Applicants: BIOGEN MA INC. [US/US]; 250 Binney Street Cambridge, MA 02142 (US)
Inventors: SALAS, Joe; (US).
TAN, Siyuan; (US).
PETERS, Robert; (US)
Agent: BRENNAN, Jack; Fish & Richardson P.C. P.O. Box 1022 Minneapolis, Minnesota 55440-1022 (US)
Priority Data:
61/827,165 24.05.2013 US
Title (EN) ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF
(FR) ANTICORPS ANTI-GPIIB/IIIA OU LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides antibodies and antigen-binding molecules thereof which specifically bind the α and/or β subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties and used, for example, as targeting moieties. The invention also includes methods for screening for these antibodies, as well as methods of making and methods of using chimeric molecules derived from the antibodies.
(FR)L'invention concerne des anticorps et des molécules de liaisons aux antigènes de ces anticorps, qui se lient spécifiquement aux sous-unités α et/ou β de la forme non active du récepteur GPIIb/IIIa. Ces anticorps et molécules de liaison aux antigènes, qui peuvent être génétiquement fusionnés et/ou conjugués à des groupes fonctionnels hétérologues, peuvent être utilisés, par exemple, comme groupes fonctionnels de ciblage. L'invention concerne également des procédés de recherche systématique de ces anticorps, ainsi que des procédés de confection et des procédés d'utilisation de molécules chimériques dérivées de ces anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)