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Machine translation
1. (WO2014190181) RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/190181    International Application No.:    PCT/US2014/039195
Publication Date: 27.11.2014 International Filing Date: 22.05.2014
IPC:
C12N 15/66 (2006.01), C12N 9/22 (2006.01), C12N 15/55 (2006.01), C12N 5/10 (2006.01)
Applicants: NORTHWESTERN UNIVERSITY [US/US]; 1800 Sherman Ave. Evanston, IL 60201 (US).
WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street, 13th Floor Madison, WI 53726 (US)
Inventors: SONTHEIMER, Erik, J.; (US).
ZHANG, Yan; (US).
MONDRAGON, Alfonso; (US).
RAJAN, Rakhi; (US).
THOMSON, James; (US).
HOU, Zhonggang; (US)
Agent: MCBRIDE, M. Scott; (US)
Priority Data:
61/826,338 22.05.2013 US
Title (EN) RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS
(FR) CLIVAGE DE L'ADN ORIENTÉ VERS ARN ET ÉDITION GÉNÉTIQUE PAR L'ENZYME CAS9 PROVENANT DE NEISSERIA MENINGITIDIS
Abstract: front page image
(EN)Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from Neisseria and one or more RNA molecules in order to direct the Cas9 protein to bind to and optionally cleave or nick a target sequence.
(FR)L'invention concerne des composants et des procédés permettant le clivage de l'ADN orienté vers ARN et l'édition génétique. Les composants comprennent et les procédés consistent à utiliser une protéine Cas9 provenant de Neisseria et une ou plusieurs molécules d'ARN afin d'orienter la protéine Cas9 pour qu'elle se lie et qu'éventuellement elle exécute un clivage ou une coupure simple brin d'une séquence cible.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)