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1. (WO2014189806) COMPOSITIONS AND METHODS FOR INHIBITING "STIMULATOR OF INTERFERON GENE" DEPENDENT SIGNALLING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/189806    International Application No.:    PCT/US2014/038526
Publication Date: 27.11.2014 International Filing Date: 18.05.2014
IPC:
A01N 43/04 (2006.01)
Applicants: ADURO BIOTECH, INC. [US/US]; 626 Bancroft Way, 3C Berkeley, CA 94710-2224 (US)
Inventors: DUBENSKY, Thomas, W., Jr.; (US).
KANNE, David, B.; (US)
Agent: WHITTAKER, Michael, A.; Acuity Law Group, P.C. 12707 High Bluff Drive, Suite 200 San Diego, CA 92130 (US)
Priority Data:
61/825,009 18.05.2013 US
61/902,125 08.11.2013 US (Priority Withdrawn 16.07.2014)
Title (EN) COMPOSITIONS AND METHODS FOR INHIBITING "STIMULATOR OF INTERFERON GENE" DEPENDENT SIGNALLING
(FR) COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE LA SIGNALISATION DÉPENDANTE DU « STIMULATEUR DES GÈNES INTERFÉRONS »
Abstract: front page image
(EN)The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon.
(FR)La présente invention concerne des composés cycliques di-nucléotidiques (CDN) qui inhibent la signalisation au niveau d'un récepteur cytoplasmique récemment découvert connu par STING (stimulateur des gènes interférons). En particulier, les CDN de la présente invention sont fournis sous la forme d'une composition comprenant un ou plusieurs di-nucléotides cycliques de type purine qui inhibent l'activation TBK1 dépendante de STING et la production résultante d'interféron de type I.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)