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Machine translation
1. (WO2014189805) COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/189805    International Application No.:    PCT/US2014/038525
Publication Date: 27.11.2014 International Filing Date: 18.05.2014
IPC:
A01N 43/04 (2006.01)
Applicants: ADURO BIOTECH, INC. [US/US]; 626 Bancroft Way, 3C Berkeley, CA 94710-2224 (US).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor Oakland, CA 94607-5200 (US)
Inventors: DUBENSKY, Thomas, W., Jr.; (US).
KANNE, David, B.; (US).
LEONG, Meredith, Lai Ling; (US).
GLICKMAN, Laura, Hix; (US).
VANCE, Russell, E.; (US).
LEMMENS, Edward, Emile; (US)
Agent: WHITTAKER, Michael, A.; Acuity Law Group, P.C. 12707 High Bluff Drive, Suite 200 San Diego, CA 92130 (US)
Priority Data:
61/902,125 08.11.2013 US
61/825,005 18.05.2013 US
Title (EN) COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING
(FR) COMPOSITIONS ET PROCÉDÉS D'ACTIVATION DE LA SIGNALISATION DÉPENDANTE DE « STIMULATEUR DE GÈNES D'INTERFÉRON »
Abstract: front page image
(EN)The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2', 5', 2', 5' and 2', 5 ',3 ',5' CDNs, and prefereably Rp,Rp stereosiomers thereof.
(FR)La présente invention concerne des stimulateurs immunitaires dinucléotidiques cycliques (CDN) hautement actifs qui activent les CD via un récepteur cytoplasmique connu sous la dénomination STING (Stimulator of Interferon Genes - stimulateur de gènes d'interféron). La présente invention concerne plus particulièrement des CDN fournis sous la forme d'une composition comprenant un ou plusieurs dinucléotides cycliques de purine stimulant la production d'interférons de type I dépendante du STING, les dinucléotides cycliques de purine présents dans la composition étant des CDN 2', 5', 2', 5' et 2', 5 ',3 ',5' sensiblement purs, et de préférence des stéréoisomères Rp,Rp correspondants.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)