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1. (WO2014189781) ENRICHED AND EXPANDED HUMAN CORD BLOOD STEM CELLS FOR TREATMENT OF HEMATOLOGICAL DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/189781    International Application No.:    PCT/US2014/038361
Publication Date: 27.11.2014 International Filing Date: 16.05.2014
IPC:
A01N 63/00 (2006.01), C12N 5/00 (2006.01), C12N 5/071 (2010.01), C12N 15/00 (2006.01)
Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; One Gustave L. Levy Place New York, NY 10029 (US)
Inventors: CHAURASIA, Pratima; (US).
HOFFMAN, Ronald; (US)
Agent: TISCHNER, Tate, L.; (US)
Priority Data:
61/983,805 24.04.2014 US
61/825,354 20.05.2013 US
Title (EN) ENRICHED AND EXPANDED HUMAN CORD BLOOD STEM CELLS FOR TREATMENT OF HEMATOLOGICAL DISORDERS
(FR) CELLULES SOUCHES ENRICHIES ET EXPANSÉES DE SANG DE CORDON HUMAIN POUR TRAITEMENT DE TROUBLES HÉMATOLOGIQUES
Abstract: front page image
(EN)This invention relates to an enriched population of isolated and expanded human cord blood stem cells and a method of producing an enriched population of isolated and expanded human cord blood stem cells. The expanded human cord blood stem cells are CD34+, CD90+, CDl 84+, CDl 17+, CD49f+, ALDH+, CD45RA- and express pluripotency genes SOX2, OCT4, NANOG, and ZIC3. In one embodiment, the stem cells in the enriched population of the present invention are positive for aldehyde dehydrogenase activity (ALDH+). In addition, in one embodiment the expanded stem cells are nearly depleted of T cells and B cells and contain a limited number of monocytes (CD14). Also disclosed is a method of treating a subject for a hematological disorder using the stem cells of the present invention and a method of determining the effects of a compound on hematopoietic stem cells.
(FR)L'invention concerne une population enrichie de cellules souches isolées et expansées de sang de cordon humain et un procédé de production d'une population enrichie de cellules souches isolées et expansées de sang de cordon humain. Les cellules souches expansées de sang de cordon humain sont CD34+, CD90+, CDl 84+, CDl 17+, CD49f+, ALDH+, CD45RA- et expriment les gènes pluripotents SOX2, OCT4, NANOG, et ZIC3. Dans un mode de réalisation, les cellules souches dans la population enrichie de la présente invention sont positives en ce qui concerne l'activité aldéhyde déshydrogénase (ALDH+). De plus, dans un mode de réalisation les cellules souches expansées sont presque démunies de cellules T et cellules B et contiennent un nombre limité de monocytes (CD14). L'invention concerne également un procédé de traitement d'un sujet atteint d'un trouble hématologique utilisant les cellules souches de la présente invention et un procédé de détermination des effets d'un composé sur les cellules souches hématopoïétiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application