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1. (WO2014189635) TRACKING DONOR-REACTIVE TCR AS A BIOMARKER IN TRANSPLANTATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/189635    International Application No.:    PCT/US2014/034685
Publication Date: 27.11.2014 International Filing Date: 18.04.2014
IPC:
C12Q 1/68 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 536 West 116th Street New York, NY 10027 (US).
ADAPTIVE BIOTECHNOLOGIES CORP. [US/US]; (US)
Inventors: SYKES, Megan; (US).
ROBINS, Harlan; (US)
Agent: LOVE, Jane, M.; Wilmer Cutler Pickering Hale And Dorr LLP 7 World Trade Center 250 Greenwich Street New York, NY 10007 (US)
Priority Data:
61/825,333 20.05.2013 US
Title (EN) TRACKING DONOR-REACTIVE TCR AS A BIOMARKER IN TRANSPLANTATION
(FR) SUIVI DU TCR RÉACTIF DU DONNEUR EN TANT QUE BIOMARQUEUR DANS UNE GREFFE
Abstract: front page image
(EN)The invention provides for the use of deep sequencing of the T-cell receptor beta CDR3 to identify, then track donor specific and/or recipient specific T cells in blood, urine and/or end-organs of transplant recipients.
(FR)L'invention concerne l'utilisation du séquençage profond du CDR3 bêta du récepteur de lymphocytes T pour identifier, puis suivre les lymphocytes T spécifiques du donneur et/ou du receveur dans le sang, l'urine et/ou les organes terminaux des receveurs de greffe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)