WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2014189331) BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/189331    International Application No.:    PCT/KR2014/004636
Publication Date: 27.11.2014 International Filing Date: 23.05.2014
IPC:
C07D 403/04 (2006.01), C07D 401/04 (2006.01), A61K 31/506 (2006.01), A61P 1/04 (2006.01)
Applicants: YUHAN CORPORATION [KR/KR]; 74, Noryangjin-ro Dongjak-gu Seoul 156-754 (KR)
Inventors: SIM, Jae Young; (KR).
CHA, Myung Hun; (KR).
KIM, Tae Kyun; (KR).
YOON, Young Ae; (KR).
KIM, Dong Hoon; (KR)
Agent: AHN, So-Young; Dr. Ahn International Patent Law Office 4th Fl., 344, Seocho-daero Seocho-gu Seoul 137-881 (KR)
Priority Data:
10-2013-0058843 24.05.2013 KR
Title (EN) BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR
(FR) DÉRIVÉ BICYCLIQUE CONTENANT UN CYCLE PYRIMIDINE, ET PROCÉDÉ DE SYNTHÈSE PERMETTANT DE L'OBTENIR
(KO) 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
Abstract: front page image
(EN)The present invention provides: a bicyclic compound derivative containing a pyrimidine ring, or a pharmaceutically acceptable salt thereof; a preparation method therefor; a pharmaceutical composition containing the same; and a use therefor. According to the present invention, the bicyclic compound derivative containing a pyrimidine ring, or a pharmaceutically acceptable salt thereof ats as a 5-HT4 receptor agonist, and thus can be usefully applied to the prevention or treatment of gastrointestinal dysmotility, for example, diseases of the digestive system such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome, indigestion, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, diabetic gastroparesis and the like.
(FR)La présente invention concerne : un dérivé de composé bicyclique contenant un cycle pyrimidine, ou un sel pharmaceutiquement acceptable de celui-ci ; un procédé de synthèse permettant de l'obtenir ; une composition pharmaceutique l'incluant ; et une utilisation dudit dérivé. Selon la présente invention, le dérivé de composé bicyclique contenant un cycle pyrimidine, ou un sel pharmaceutiquement acceptable de celui-ci, agit en tant qu'agoniste de récepteur 5-HT4, et peut donc être appliqué de façon utile au traitement prophylactique ou thérapeutique de la dysmotilité gastro-intestinale, par exemple des maladies du système digestif telles que le reflux gastro-œsophagien (RGO), la constipation, les maladies inflammatoires chroniques de l'intestin, l'indigestion, l'occlusion intestinale postopératoire, le retard de transit induit par médicament, la gastroparésie diabétique, etc.
(KO)본 발명은 피리미딘 고리를 포함하는 바이사이클릭 화합물 유도체 또는 그의 약학적으로 허용가능한 염, 이의 제조방법, 이를 포함하는 약학 조성물, 및 이의 용도를 제공한다. 본 발명에 따른 피리미딘 고리를 포함하는 바이사이클릭 화합물 유도체 또는 그의 약학적으로 허용가능한 염은 5-HT4 수용체 효능제로서 작용함으로써, 위장관 운동장애, 예를 들어 역류성식도염(GERD), 변비, 과민성대장증후군, 소화불량, 수술 후 장폐색, 위 배출 지연증, 위마비증, 가성 장 폐색증, 약물로-유도된 통과 지연증, 또는 당뇨병성 위무력증 등과 같은 소화기계 질환의 예방 또는 치료에 유용하게 적용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)