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1. (WO2014189201) COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, COMPRISING, AS ACTIVE INGREDIENT, PINK1 PROTEIN OR POLYNUCLEOTIDE ENCODING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/189201    International Application No.:    PCT/KR2014/002457
Publication Date: 27.11.2014 International Filing Date: 24.03.2014
IPC:
A61K 38/16 (2006.01), A61K 48/00 (2006.01), A61K 38/17 (2006.01), A61P 37/00 (2006.01)
Applicants: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION [KR/KR]; Songeui Campus, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 137-701 (KR)
Inventors: CHO, Mi-La; (KR).
RHIM, Hyang-Shuk; (KR).
LEE, Seon-Yeong; (KR).
MUN, Yeong-Mi; (KR).
SON, Hye-Jin; (KR).
YANG, Eun-Ji; (KR).
KIM, Eun-Kyung; (KR)
Agent: BAE, KIM & LEE IP GROUP; 11th Floor, 343, Gangnam-daero, Seocho-gu, Seoul 137-858 (KR)
Priority Data:
10-2013-0057659 22.05.2013 KR
Title (EN) COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, COMPRISING, AS ACTIVE INGREDIENT, PINK1 PROTEIN OR POLYNUCLEOTIDE ENCODING SAME
(FR) COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE COMPRENANT EN TANT QUE PRINCIPE ACTIF LA PROTÉINE PINK1 OU UN POLYNUCLÉOTIDE CODANT POUR CELLE-CI
(KO) PINK1 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a composition for preventing or treating autoimmune disease, comprising, as an active ingredient, PINK1 protein or polynucleotide encoding same. The PINK1 protein according to the present invention inhibits the activity of Th17, promotes the activity of a regulatory T cell (Treg), and increases autophagy in Treg cells, thereby controlling excessive immune responses. Therefore, the PINK1 protein can be effectively used as a pharmaceutical composition or an immunosuppressant, which is capable of preventing or treating autoimmune disease, such as arthritis, etc., caused by dysregulation of various kinds of immune responses.
(FR)La présente invention concerne une composition pour la prévention ou le traitement d'une maladie auto-immune comprenant en tant que principe actif la protéine PINK1 ou un polynucléotide codant pour celle-ci. La protéine PINK1 selon la présente invention inhibe l'activité de Th17, favorise l'activité d'un lymphocyte T régulateur (Treg) et augmente l'autophagie dans les lymphocytes Treg, régulant ainsi les réponses immunitaires excessives. De ce fait, la protéine PINK1 peut être efficacement utilisée en tant que composition pharmaceutique ou immunosuppresseur, qui est capable de prévenir ou de traiter une maladie auto-immune comme l'arthrite, etc., provoquée par une dérégulation de plusieurs types de réponses immunitaires.
(KO)본 발명은 PINK1 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 PINK1 단백질은 Th17의 활성을 억제시키거나, 조절 T 세포(Regulatory T cell: Treg)의 활성을 촉진시키며, Treg 세포에서 자가소화작용을 증가시켜 과도한 면역반응을 조절하는 기작을 통해 이루어지므로 관절염 등 각종 면역반응의 조절 이상으로 유발되는 자가면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)