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1. (WO2014188368) A METHOD FOR GREY ZONE IMAGING USING RELATIVE R1 CHANGES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/188368    International Application No.:    PCT/IB2014/061620
Publication Date: 27.11.2014 International Filing Date: 22.05.2014
IPC:
A61B 5/055 (2006.01), A61B 5/00 (2006.01), G01R 33/48 (2006.01)
Applicants: KONINKLIJKE PHILIPS N.V. [NL/NL]; High Tech Campus 5 NL-5656 AE Eindhoven (NL) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
PHILIPS DEUTSCHLAND GMBH [DE/DE]; Lübeckertordamm 5 20099 Hamburg (DE) (DE only).
KING'S COLLEGE LONDON [GB/GB]; Strand London WC2R 2LS (GB) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only)
Inventors: VOIGT, Tobias Ratko; (NL).
WIETHOFF, Andrea Jane; (NL).
SCHAEFFTER, Tobias Richard; (NL).
RAZAVI, Reza; (NL).
CHEN, Zhong; (NL).
RINALDI, Christopher Aldo; (NL)
Agent: STEFFEN, Thomas; High Tech Campus Building 5 NL-5656 AE Eindhoven (NL)
Priority Data:
61/826,187 22.05.2013 US
Title (EN) A METHOD FOR GREY ZONE IMAGING USING RELATIVE R1 CHANGES
(FR) PROCÉDÉ DE FORMATION D'IMAGE À ZONE GRISE FAISANT APPEL À DES CHANGEMENTS RELATIFS DE R1
Abstract: front page image
(EN)A medical system (10) and method (100) characterizes myocardium. A pre-contrast magnetic resonance (MR) data set and a post-contrast MR data set of the myocardium are generated using a cardiac T1 mapping sequence. The pre-and post-contrast MR data sets are reconstructed to pre-and post-contrast T1 maps, respectively. A map of the relative change in an R1 relaxivity of a contrast agent is calculated from the pre-and post- contrast T1 maps. The contrast agent is used to generate the pre- and post-contrast MR data sets, and the R1 relaxivity is the inverse of T1. Values of the map of relative change in the R1 relaxivity are compared to cutoffs to discriminate between grey zone and another type of myocardium. Grey zone is a mixture of normal and fibrotic myocardium.
(FR)L'invention porte sur un système médical (10) et sur un procédé (100) qui permettent de caractériser le myocarde. L'invention consiste à générer un ensemble de données de résonance magnétique (RM) de pré-contraste et un ensemble de données RM de post-contraste du myocarde au moyen d'une séquence de cartographie cardiaque T1 ; à reconstruire les ensembles de données RM de pré-contraste et de post-contraste sur des cartes T1 de pré-contraste et de post-contraste, respectivement ; et à calculer une carte du changement relatif de la relaxivité R1 d'un agent de contraste à partir des cartes T1 de pré-contraste et de post-contraste. On utilise l'agent de contraste pour générer les ensembles de données RM de pré-contraste et de post-contraste, la relaxivité R1 étant l'inverse de T1, et l'on compare les valeurs de la carte du changement relatif de la relaxivité R1 à des valeurs limites afin de distinguer la zone grise d'un autre type de myocarde. La zone grise correspond à un mélange de myocarde normal et fibreux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)