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1. (WO2014187881) ISOFORMS OF GATA6 AND NKX2-1 AS MARKERS FOR DIAGNOSIS AND THERAPY OF CANCER AND AS TARGETS FOR ANTI-CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/187881    International Application No.:    PCT/EP2014/060489
Publication Date: 27.11.2014 International Filing Date: 21.05.2014
IPC:
C12Q 1/68 (2006.01)
Applicants: MAX-PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE/DE]; Hofgartenstraße 8 80539 München (DE).
JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN [DE/DE]; Ludwigstrasse 23 35390 Gießen (DE)
Inventors: BARRETO, Guillermo; (DE).
MEHTA, Aditi; (DE).
SINGH, Indrabahadur; (DE).
SZIBOR, Marten; (FI).
SAVAI, Rajkumar; (DE).
SEEGER, Werner; (DE).
BRAUN, Thomas; (DE).
GÜNTHER, Andreas; (DE).
KRÜGER, Marcus; (DE)
Agent: JÜRGEN MEIER, VOSSIUS & PARTNER; Siebertstraße 4 81675 München (DE)
Priority Data:
13168629.7 21.05.2013 EP
13168636.2 21.05.2013 EP
Title (EN) ISOFORMS OF GATA6 AND NKX2-1 AS MARKERS FOR DIAGNOSIS AND THERAPY OF CANCER AND AS TARGETS FOR ANTI-CANCER THERAPY
(FR) ISOFORMES DE GATA6 ET DE NKX2-1 UTILISÉS EN TANT QUE MARQUEURS POUR LE DIAGNOSTIC ET LA CANCÉROTHÉRAPIE ET EN TANT QUE CIBLES POUR UNE THÉRAPIE ANTICANCÉREUSE
Abstract: front page image
(EN)The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer.
(FR)L'invention concerne un procédé pour évaluer si un sujet souffre d'un cancer ou est susceptible de souffrir d'un cancer, en particulier d'un cancer du poumon, consistant à mesurer les quantités d'isoformes spécifiques de GATA6 et/ou de NKX2-1 dans un échantillon du sujet. L'invention concerne également une composition utilisée en médecine comprenant un/des inhibiteur(s) d'isoformes spécifiques de GATA6 et/ou de NKX2-1. L'invention concerne en outre un kit utilisé dans le procédé pour évaluer si un sujet souffre d'un cancer ou est susceptible de souffrir d'un cancer, en particulier d'un cancer du poumon.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)