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1. (WO2014187879) NOVEL ANTIBODY USEFUL IN NEUROLOGICAL OR NEURODEGENERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/187879    International Application No.:    PCT/EP2014/060486
Publication Date: 27.11.2014 International Filing Date: 21.05.2014
IPC:
C07K 16/28 (2006.01), A61P 9/10 (2006.01), A61P 25/00 (2006.01)
Applicants: PAION DEUTSCHLAND GMBH [DE/DE]; Martinstraße 10 - 12 52062 Aachen (DE).
INSERM [FR/FR]; 101 rue de Tolbiac F-75013 Paris (FR)
Inventors: DOCAGNE, Fabian; (FR).
MACREZ, Richard; (FR).
VIVIEN, Denis; (FR).
PETERSEN, Karl-Uwe; (DE)
Agent: VON RENESSE, Dorothea; Mönchenwerther Straße 11 40545 Düsseldorf (DE)
Priority Data:
13002641.2 21.05.2013 EP
13002850.9 03.06.2013 EP
Title (EN) NOVEL ANTIBODY USEFUL IN NEUROLOGICAL OR NEURODEGENERATIVE DISORDERS
(FR) NOUVEL ANTICORPS UTILISÉ DANS LES TROUBLES NEUROLOGIQUES OU NEURODÉGÉNÉRATIFS
Abstract: front page image
(EN)The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of tissue-type plasminogen activator (t-PA) mediated by N-methyl-D-aspartate (NMDA) receptors and to medical uses, in particular for the treatment of neurological or neurodegenerative disorders, e.g. multiple sclerosis.
(FR)L'invention concerne un anticorps anti-NMDA ou un fragment ou un dérivé de celui-ci efficace pour inhiber les effets délétères d'un activateur de plasminogène de type tissulaire (t- PA) médié par des récepteurs de N-methyl-D-aspartate (NMDA), et ses utilisations médicales, en particulier pour traiter les troubles neurologiques ou neurodégénératifs, par exemple la sclérose en plaques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)