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1. (WO2014187777) NOVEL INHIBITORS OF PVHL-ELONGIN C BINDING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/187777    International Application No.:    PCT/EP2014/060246
Publication Date: 27.11.2014 International Filing Date: 19.05.2014
IPC:
A61K 31/404 (2006.01), A61K 31/41 (2006.01), A61K 31/4245 (2006.01), A61K 31/4709 (2006.01), A61P 9/10 (2006.01), A61K 47/48 (2006.01)
Applicants: MEDIAPHARMA S.R.L. [IT/IT]; Via Colle dell´Ara I-66013 Chieti (IT).
ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA [IT/IT]; Via Zamboni, 33 I-40126 Bologna (IT)
Inventors: IACOBELLI, Stefano; (IT).
TINARI, Nicola; (IT).
FALCHI, Federico; (IT).
RECANATINI, Maurizio; (IT).
FICHERA, Imma; (IT).
PICCOLO, Enza; (IT)
Agent: HEUBECK, Christian; Weickmann & Weickmann Postfach 860 820 81679 München (DE)
Priority Data:
61/825,599 21.05.2013 US
Title (EN) NOVEL INHIBITORS OF PVHL-ELONGIN C BINDING
(FR) NOUVEAUX INHIBITEURS DE LA LIAISON ÉLONGINE C-PVHL
Abstract: front page image
(EN)The present invention relates to novel inhibitors of pVHL-Elongin C binding, methods for identifying such inhibitors as well as compounds comprising a first moiety binding to an Elongin B, Elongin C, Cul2 and/or Rbx1 complex, a linker and a second moiety for HIF-2α.
(FR)La présente invention concerne de nouveaux inhibiteurs de la liaison Élongine C-pVHL, des procédés d'identification de tels inhibiteurs, ainsi que des composés comprenant une première fraction se liant à l'Élongine B, l'Élongine C, Cul2 et/ou au complexe Rbx1, un segment de liaison et une deuxième fraction de HIF -2 alpha.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)