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1. (WO2014187768) NOVEL SYNTHETIC PROCESSES TO 8-CHLORO-3-BENZO[D]AZEPINE VIA FRIEDEL-CRAFTS ALKYLATION OF OLEFIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/187768    International Application No.:    PCT/EP2014/060221
Publication Date: 27.11.2014 International Filing Date: 19.05.2014
IPC:
C07D 223/16 (2006.01)
Applicants: LEK PHARMACEUTICALS D.D. [SI/SI]; Verovskova 57 1526 Ljubljana (SI)
Inventors: STAVBER, Gaj; (SI).
CLUZEAU, Jerome; (SI)
Agent: KLUSCHANZOFF, Harald; Industriestr. 25 83607 Holzkirchen (DE)
Priority Data:
13168419.3 20.05.2013 EP
Title (EN) NOVEL SYNTHETIC PROCESSES TO 8-CHLORO-3-BENZO[D]AZEPINE VIA FRIEDEL-CRAFTS ALKYLATION OF OLEFIN
(FR) NOUVEAUX PROCÉDÉS DE SYNTHÈSE D'UNE 8-CHLORO-3-BENZO[D]AZÉPINE PAR ALKYLATION DE FRIEDEL-CRAFTS D'OLÉFINE
Abstract: front page image
(EN)The present invention is directed to a short, facile, effective and industrially applicable process for obtaining 8-chloro-l-methyl-2,3,4,5-tetrahydro-lH- benzo[d]azepine, or its salt, preferably lorcaserin hydrochloride. The present invention is further directed to a simple and effective ring closing methodology for obtaining 8-chloro-l-methyl-2,3,4,5-tetrahydro-lH- benzo[d]azepine, or its salt, preferably lorcaserin hydrochloride. The present invention is also directed to a novel intermediate which can be suitably used in the process for producing 8-chloro-l-methyl-2, 3,4,5- tetrahydro-lH-benzo[d]azepine, or its salt, preferably lorcaserin hydrochloride and to a process for producing the novel intermediate.
(FR)La présente invention porte sur un procédé court, facile et efficace, applicable à l'échelle industrielle, de production de la 8-chloro-l-méthyl-2,3,4,5-tétrahydro-lH- benzo[d]azépine ou de son sel, de préférence un hydrochlorure de lorcasérine. L'invention concerne en outre une méthodologie de fermeture de cycle simple et efficace permettant d'obtenir la 8-chloro-l-méthyl-2,3,4,5-tétrahydro-lH- benzo[d]azépine ou son sel, de préférence un hydrochlorure de lorcasérine. La présente invention concerne également un nouvel intermédiaire utilisable dans le procédé de production de la 8-chloro-l-méthyl-2,3,4,5-tétrahydro-lH- benzo[d]azépine ou de son sel, de préférence un hydrochlorure de lorcasérine, ainsi qu'un procédé de production dudit nouvel intermédiaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)